Journal
TRENDS IN MICROBIOLOGY
Volume 16, Issue 1, Pages 1-5Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tim.2007.11.001
Keywords
-
Categories
Funding
- NCI NIH HHS [CA096878, CA108697] Funding Source: Medline
- NIAID NIH HHS [AI026765] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA108697, R01CA096878] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI026765, R56AI026765] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Eukaryotic mRNA initiates translation by cap-dependent scanning, ribosome shunting and cap-independent internal ribosome entry. Internal ribosome entry was first discovered for cytoplasmic RNA viruses but has also been identified for DNA viruses and cellular mRNAs. An internal ribosome entry site (IRES) directs internal binding of ribosomes and nucleates the formation of a translation initiation complex. Current research is aimed at identifying interactions between IRES elements and RNA-binding proteins known as ITAFs (IRES trans-acting factors). Here we compare IRES elements from cytoplasmic RNA viruses with those of cellular mRNAs and DNA viruses with nuclear mRNA synthesis, and suggest that ITAF composition and IRES function directly reflect the site of synthesis of mRNA and the history of its pathway to polysomes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available