4.6 Editorial Material

'NOTCHing up' the In Vitro Production of Dendritic Cells

Journal

TRENDS IN IMMUNOLOGY
Volume 39, Issue 10, Pages 765-767

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.it.2018.08.002

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Funding

  1. Sir Henry Wellcome Post-doctoral Fellowship
  2. FWO
  3. GOA-Ghent University
  4. ERC Consolidator grant

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Two studies show that adding NOTCH ligands to Flt3L cultures increases the yield of cDC1s from mouse and human progenitors. Moreover, these NOTCH-DCs more closely resemble in vivo DCs transcriptionally and functionally. This will be extremely valuable for studying DCs in vitro and for further developing autologous DC-based antitumor vaccinations.

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