Journal
TRENDS IN IMMUNOLOGY
Volume 39, Issue 10, Pages 765-767Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2018.08.002
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Funding
- Sir Henry Wellcome Post-doctoral Fellowship
- FWO
- GOA-Ghent University
- ERC Consolidator grant
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Two studies show that adding NOTCH ligands to Flt3L cultures increases the yield of cDC1s from mouse and human progenitors. Moreover, these NOTCH-DCs more closely resemble in vivo DCs transcriptionally and functionally. This will be extremely valuable for studying DCs in vitro and for further developing autologous DC-based antitumor vaccinations.
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