Journal
TRENDS IN IMMUNOLOGY
Volume 35, Issue 11, Pages 549-561Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2014.08.007
Keywords
HIV-1; antibodies; B cells; adaptive immunity; viruses
Categories
Funding
- European Research Council (ERC) [ERC-2013-StG 337146]
- G5 Institut Pasteur Program
- Milieu Interieur Program [ANR-10-LABX-69-01]
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In rare cases, B cells can supply HIV-1-infected individuals with unconventional antibodies equipped to neutralize the wide diversity of viral variants. Innovations in single-cell cloning, high-throughput sequencing, and structural biology methods have enabled the capture and thorough characterization of these exceptionally potent broadly neutralizing antibodies (bNAbs). Here, I review the recent findings in humoral responses to HIV-1, focusing on the interplay between naturally occurring bNAbs and the virus both at systemic and mucosa! levels. In this context, I discuss how an improved understanding of bNAb generation may provide invaluable insight into the fundamental mechanisms governing adaptive B cell responses to viruses, and how this knowledge is currently contributing to the development of vaccine and therapeutic strategies against HIV-1.
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