Journal
TRENDS IN IMMUNOLOGY
Volume 35, Issue 1, Pages 12-21Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2013.10.008
Keywords
eicosanoids; prostaglandins; cyclooxygenase; resolution of inflammation; sepsis; immunosuppression
Categories
Funding
- Wellcome Trust
- National Institute for Health Research [ACF-2010-18-029] Funding Source: researchfish
Ask authors/readers for more resources
Sepsis, trauma, burns, and major surgical procedures activate common systemic inflammatory pathways. Nosocomial infection, organ failure, and mortality in this patient population are associated with a quantitatively different reprioritization of the circulating leukocyte transcriptome to the initial inflammatory insult, greater in both magnitude and duration, and secondary to multiple observed defects in innate and adaptive immune function. Dysregulation of inflammatory resolution processes and associated bioactive lipid mediators (LMs) mechanistically contribute to this phenotype. Recent data indicate the potential efficacy of therapeutic interventions that either reduce immunosuppressive prostaglandins (PGs) or increase specialized proresolving LMs. Here, we reassess the potential for pharmacological manipulation of these LMs as therapeutic approaches for the treatment of critical illness (CI).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available