Journal
TRENDS IN IMMUNOLOGY
Volume 35, Issue 6, Pages 262-269Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2014.02.008
Keywords
exercise; muscle; immune cells; inflammation; metabolic disease; anti-inflammatory
Categories
Funding
- Australian Research Council
- National Health and Medical Research Council (NHMRC)
- NHMRC
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A lack of physical activity is linked to the development of many chronic diseases. It is now well established that the immune system and inflammation play a central role in the development of numerous chronic metabolic diseases including insulin resistance, type 2 diabetes, atherosclerosis, nonalcoholic fatty liver disease, and specific types of cancer. Physical exercise elicits potent anti-inflammatory effects that are likely to account for many of the salutary actions of regular exercise on chronic metabolic diseases. Here we review the anti-inflammatory and immunomodulatory mechanisms by which the beneficial effects of exercise on chronic metabolic diseases may be mediated.
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