Journal
TRENDS IN IMMUNOLOGY
Volume 35, Issue 9, Pages 429-435Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2014.06.003
Keywords
DNA sensors; DNA damage; DNA repair; innate immunity; inflammation
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Funding
- NSRF-ESPA [EDGE 901-13/11/2009]
- THALIS (ESPA)
- GenAge
- miREG
- ARISTEIA TagNER
- NSRF [ELKE 901-13/11/2009]
- FP7 Marie Curie ITN aDDRess, Code Age, and Marriage
- Maria-Michail Manassakis Fellowship
- EMBO Young Investigator program
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To counteract DNA damage, cells employ genome maintenance pathways that are directed inward, relentlessly to scan and repair the genome. Adaptive and innate immune mechanisms are often directed outward, protecting self against pathogens. Recent work has revealed direct links between innate immune signaling and the DNA damage response (DDR). Here we review current understanding of the mechanism by which cells sense damaged and foreign DNA. We examine the functional role of DNA damage signaling in immune activation and discuss the relevance of these processes to DNA damage-driven chronic inflammation in disease and in aging.
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