Journal
TRENDS IN IMMUNOLOGY
Volume 35, Issue 9, Pages 408-419Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2014.07.005
Keywords
long noncoding RNA; antisense; lincRNA; inflammation; innate immune response; adaptive immune response
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Funding
- BBSRC [BB/K006223/1]
- BBSRC [BB/K006223/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/K006223/1] Funding Source: researchfish
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It is increasingly clear that long non-coding RNAs (IncRNAs) regulate a variety biological responses, and that they do so by a diverse range of mechanisms. In the field of immunology, recent publications have shown widespread changes in the expression of IncRNAs during the activation of the innate immune response and T cell development, differentiation, and activation. These IncRNAs control important aspects of immunity such as production of inflammatory mediators, differentiation, and cell migration through regulating protein-protein interactions or via their ability to basepair with RNA and DNA. We review the current understanding of the mechanism of action of these immune-related IncRNAs, discuss their impact on physiological and pathological processes, and highlight important areas of inquiry at the intersection between immunology and IncRNA biology.
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