Journal
TRENDS IN IMMUNOLOGY
Volume 35, Issue 11, Pages 562-570Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2014.09.005
Keywords
plant defense; innate immunity; NLR pairs; transcriptional reprogramming
Categories
Funding
- Max Planck Society
- DFG Collaborative Research Center [SFB 670]
Ask authors/readers for more resources
Intracellular nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are basic elements of innate immunity in plants and animals. Whereas animal NLRs react to conserved microbe- or damage-associated molecular patterns, plant NLRs intercept the actions of diverse pathogen virulence factors (effectors). In this review, we discuss recent genetic and molecular evidence for functional NLR pairs, and discuss the significance of NLR self-association and heteromeric NLR assemblies in the triggering of downstream signaling pathways. We highlight the versatility and impact of cooperating NLR pairs that combine pathogen sensing with the initiation of defense signaling in both plant and animal immunity. We propose that different NLR receptor molecular configurations provide opportunities for fine-tuning resistance pathways and enhancing the host's pathogen recognition spectrum to keep pace with rapidly evolving microbial populations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available