Journal
TRENDS IN IMMUNOLOGY
Volume 35, Issue 1, Pages 22-31Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2013.10.005
Keywords
A20; tumor necrosis factor alpha-induced protein 3; nuclear factor-kappa B; inflammation; apoptosis; ubiquitination
Categories
Funding
- FWO
- Geneeskundige Stichting Koningin Elisabeth (GSKE)
- Charcot Foundation
- Interuniversity Attraction Poles program [IAP7/32]
- Belgian Foundation against Cancer
- Strategic Basis Research program of the IWT
- Group-ID MRP initiative of the Ghent University
- GOA initiative of the Ghent University
- Hercules initiative of the Ghent University
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Although known for many years as a nuclear factor (NF)-kappa B inhibitory and antiapoptotic signaling protein, A20 has recently attracted much attention because of its ubiquitin-regulatory activities and qualification by genome-wide association studies (GWASs) as a susceptibility gene for inflammatory disease. Here, we review new findings that have shed light on the molecular and biochemical mechanisms by which A20 regulates inflammatory signaling cascades, and discuss recent experimental evidence characterizing A20 as a crucial gatekeeper preserving tissue homeostasis.
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