Journal
TRENDS IN IMMUNOLOGY
Volume 35, Issue 8, Pages 379-386Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2014.05.005
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Funding
- NCI NIH HHS [R21 CA167601] Funding Source: Medline
- NHLBI NIH HHS [U01 HL111054, R01 HL107386, P01 HL024136] Funding Source: Medline
- NIAID NIH HHS [U19 AI077439, T32 AI007334] Funding Source: Medline
- NICHD NIH HHS [K12 HD000850, K12 HD072222] Funding Source: Medline
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The lung is a complex structure that is interdigitated with immune cells. Understanding the 4D process of normal and defective lung function and immunity has been a centuries-old problem. Challenges intrinsic to the lung have limited adequate microscopic evaluation of its cellular dynamics in real time, until recently. Because of emerging technologies, we now recognize alveolar-to-airway transport of inhaled antigen. We understand the nature of neutrophil entry during lung injury and are learning more about cellular interactions during inflammatory states. Insights are also accumulating in lung development and the metastatic niche of the lung. Here we assess the developing technology of lung imaging, its merits for studies of pathophysiology and areas where further advances are needed.
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