Journal
TRENDS IN IMMUNOLOGY
Volume 35, Issue 7, Pages 299-310Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2014.04.007
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Funding
- U.S. National Institutes of Health (NIH) grant [1R01AI100135-01]
- Global Health award from the Bill & Melinda Gates Foundation [OPPGH5284]
- Grand Challenges Explorations award from the Bill & Melinda Gates Foundation [OPP1035192]
- VentiRx Pharmaceuticals
- 3M Drug Delivery Systems
- MedImmune
- Crucell (Johnson Johnson)
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The human immune system comprises cellular and molecular components designed to coordinately prevent infection while avoiding potentially harmful inflammation and autoimmunity. Immunity varies with age, reflecting unique age-dependent challenges including fetal gestation, the neonatal phase, and infancy. Here, we review novel mechanistic insights into early life immunity, with an emphasis on emerging models of human immune ontogeny, which may inform age-specific translational development of novel anti-infectives, immunomodulators, and vaccines.
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