Journal
TRENDS IN IMMUNOLOGY
Volume 34, Issue 6, Pages 251-258Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2013.02.005
Keywords
natural killer cells; adaptive immunity; immunological memory
Categories
Funding
- National Institutes of Health [AI066897, AI068129, CA095137]
- Uehara Memorial Foundation
- Natio Foundation
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Japan Society for the Promotion of Science
- American Lung Association Senior Research Training Fellowship
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Immunological memory has traditionally been regarded as a unique feature of the adaptive immune response, mediated in an antigen-specific manner by T and B lymphocytes. All other hematopoietic cells, including natural killer (NK) cells, are classified as innate immune cells, which have been considered short-lived but can respond rapidly against pathogens in a manner not thought to be driven by antigen. Interestingly, NK cells have recently been shown to survive long term after antigen exposure and subsequently mediate antigen-specific recall responses. In this review, we address the similarities between, and the controversies surrounding, three major viewpoints of NK memory that have arisen from these recent studies: (i) mouse cytomegalovirus (MCMV)-induced memory; (ii) cytokine-induced memory; and (iii) liver-restricted memory cells.
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