Journal
TRENDS IN IMMUNOLOGY
Volume 34, Issue 9, Pages 423-430Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2013.07.001
Keywords
Gut microbiome; Mucosal regulatory T cells; Anti-inflammatory organisms; Proinflammatory (colitogenic organisms); Inflammatory Bowel Disease
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Funding
- Intramural NIH HHS [ZIA AI000354-27] Funding Source: Medline
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In the past 10 years it has become increasingly apparent that the gut microbiome has profound effects on the immune system to which it is juxtaposed, the mucosal immune system. Here, I explore recent studies in which the effects of the microbiota expand or facilitate anti-inflammatory or regulatory immunological machinery or which favor development of proinflammatory immunological machinery in this system. I then focus on how these opposing processes play out in inflammatory bowel disease (IBD); a disease in which normal immune homeostasis is disturbed and inflammation takes hold.
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