Journal
TRENDS IN IMMUNOLOGY
Volume 34, Issue 5, Pages 200-207Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2013.01.001
Keywords
T follicular helper cells; Bcl-6; histone modification; T cell plasticity
Categories
Funding
- Intramural NIH HHS [Z99 HL999999, Z99 HG999999, ZIA HG000123, ZIA HG000123-13, ZIA HG000123-14, Z99 MH999999, ZIA HG000123-15] Funding Source: Medline
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CD4(+) T helper (Th) cells play an instrumental role in orchestrating adaptive immune responses to invading pathogens through their ability to differentiate into specialized effector subsets. Part of this customized response requires the development of T follicular helper (Tfh) cells, which provide help to B cells for the generation of germinal centers (GCs) and long-term protective humoral responses. Although initially viewed as terminally differentiated, we now recognize that Th cell subsets, including Tfh cells, display substantial flexibility and overlap in their characteristics. In this review, we highlight advances in our understanding of Tfh cell development, cytokine production, and the potential plasticity that allows Tfh cells to possess characteristics of other effector Th cell populations.
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