Journal
TRENDS IN IMMUNOLOGY
Volume 34, Issue 7, Pages 350-359Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2013.02.003
Keywords
miRNA; inflammation; monocyte; tumor-associated macrophage; cancer
Categories
Funding
- European Research Council (ERC)
- National Centres of Competence in Research (Oncology Program)
- Fonds National Suisse de la Recherche Scientifique (SNSF)
- Anna Fuller fund
- US National Institutes of Health (NIH) [R01-AI084880, P50-CA086355, U54-CA126515]
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Deregulation of microRNAs (miRNAs) can drive oncogenesis, tumor progression, and metastasis by acting cell-autonomously in cancer cells. However, solid tumors are also infiltrated by large amounts of non-neoplastic stromal cells, including macrophages, which express several active miRNAs. Tumor-associated macrophages (TAMs) enhance angiogenic, immunosuppressive, invasive, and metastatic programming of neoplastic tissue and reduce host survival. Here, we review the role of miRNAs (including miR-155, miR-146, and miR-511) in the control of macrophage production and activation, and examine whether reprogramming miRNA activity in TAMs and/or their precursors might be effective for controlling tumor progression.
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