Journal
TRENDS IN IMMUNOLOGY
Volume 33, Issue 12, Pages 633-640Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2012.10.005
Keywords
HMGB proteins; PRRs; DAMPs; nucleic acids; innate immunity; inflammation
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Core Research for Evolutional Science and Technology (CREST) of the Japan Science and Technology Agency (JST)
- Grants-in-Aid for Scientific Research [22114007, 24590574] Funding Source: KAKEN
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Recent discoveries in signal-transducing innate receptors have illustrated the close link between innate and adaptive immunity. These advances revisit a fundamental issue of immunology, the recognition of self and nonself molecules by the immune system. Indeed, mounting evidence has been provided that the sensing of self-derived molecules by the immune system is important for health and disease. The high-mobility group box (HMGB) proteins, particularly HMGB1, are self-derived immune activators that have multiple functions in the regulation of immunity and inflammation. In this review, we summarize current knowledge of the function of HMGB proteins, as a ligand that can evoke inflammatory responses, and as a sensor for nucleic-acid-mediated immune responses.
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