Journal
TRENDS IN IMMUNOLOGY
Volume 33, Issue 6, Pages 281-288Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2012.04.003
Keywords
memory; antibodies; affinity maturation; humoral immunity; cytokines
Categories
Ask authors/readers for more resources
The humoral immune system generates immunological memory comprising affinity matured, long-lived memory B cells and plasma cells (PCs), which are generated primarily in germinal centres (GCs). Although many factors are essential in this process, those that specifically govern B cell fate are not fully understood. The provision of T cell help to B cells is key in GC B cell fate determination, and it has become clear recently that this help involves more than direct cell cell interactions. Recently, the cytokine interleukin (IL)-21 has been identified as a key factor that can modulate the processes within GCs and directly influence B cell fate. In this review, we examine the roles of GC cytokines in the context of cell differentiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available