Journal
TRENDS IN IMMUNOLOGY
Volume 33, Issue 8, Pages 397-405Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2012.03.003
Keywords
phagocytosis; phagosome maturation; phosphoinositide; GTPase; calcium; autophagy; membrane fusion; membrane fission
Categories
Funding
- Cystic Fibrosis Canada
- Canadian Institutes of Health Research (CIHR)
Ask authors/readers for more resources
Phagocytosis mediates the clearance of apoptotic bodies and also the elimination of microbial pathogens. The nascent phagocytic vacuole formed upon particle engulfment lacks microbicidal and degradative activity. These capabilities are acquired as the phagosome undergoes maturation; a progressive remodeling of its membrane and contents that culminates in the formation of phagolysosomes. Maturation entails orderly sequential fusion of the phagosomal vacuole with specialized endocytic and secretory compartments. Concomitantly, the phagosomal membrane undergoes both inward and outward vesiculation and tubulation followed by fission, thereby recycling components and maintaining its overall size. Here, we summarize what is known about the molecular machinery that governs this complex metamorphosis of phagosome maturation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available