Journal
TRENDS IN IMMUNOLOGY
Volume 33, Issue 2, Pages 84-90Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2011.11.005
Keywords
T cells; viral infections; memory cells; cytomegalovirus
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Funding
- Marie Curie Fellowship
- Wellcome Trust
- National Institute for Health Research [NF-SI-0510-10204] Funding Source: researchfish
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Typically, during viral infections, T cells encounter antigen, undergo proliferative expansion and ultimately contract into a pool of memory cells. However, after infection with cytomegalovirus, a ubiquitous beta-herpesvirus, T cell populations specific for certain epitopes do not contract but instead are maintained and/or accumulate at high frequencies with a characteristic effector-memory phenotype. This feature has also been noted after other infections, for example, by parvoviruses. We discuss this so-called memory T cell inflation and the factors involved in this phenomenon. Also, we consider the potential therapeutic use of memory T cell inflation as a vaccine strategy and the associated implications for immune senescence.
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