Journal
TRENDS IN IMMUNOLOGY
Volume 33, Issue 4, Pages 168-173Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2012.01.010
Keywords
-
Categories
Funding
- National Institutes of Health [R01 AI063345, R01 HL108006]
- American Asthma Foundation
- Lupus Research Institute
- Leukemia and Lymphoma Society
Ask authors/readers for more resources
T cell growth and function must be tightly regulated to provide protection against foreign pathogens, while avoiding autoimmunity and immunodeficiency. It is now apparent that T cell metabolism is highly dynamic and has a tremendous impact on the ability of T cells to grow, activate and differentiate. Specific metabolic pathways provide energy and biosynthetic precursors that must support specific cell functions, as effector, regulatory, memory, and alloreactive T cells have distinct metabolic needs in immunity and inflammation. Here, we review the signaling pathways that control metabolism and how the metabolic phenotypes of T cell subtypes integrate with T cell function. Ultimately, these metabolic differences may provide new opportunities to modulate the immune response and treat inflammatory and autoimmune diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available