Journal
TRENDS IN IMMUNOLOGY
Volume 32, Issue 8, Pages 373-379Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2011.05.004
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Funding
- NHLBI NIH HHS [R01 HL093262-01A1, R01 HL093262] Funding Source: Medline
- NIAID NIH HHS [R01 AI083713-01, R01 AI083713] Funding Source: Medline
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A strong link between inflammation and metabolism is becoming increasingly evident. A number of recent landmark studies have implicated the activation of the NLRP3 inflammasome, an interleukin-10 family cytokine-activating protein complex, in a variety of metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review these new developments and discuss their implications for a better understanding of inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.
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