Journal
TRENDS IN IMMUNOLOGY
Volume 32, Issue 1, Pages 26-33Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2010.10.005
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Funding
- National Institute of Arthritis, Musculoskeletal and Skin Diseases [KO1 AR053595, RO1 AR060723]
- Starr Cancer Consortium [13-A123]
- Arthritis Foundation
- Rita Allen Foundation
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR060723, K01AR053595] Funding Source: NIH RePORTER
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The forkhead box O (Foxo) family of transcription factors consists of the mammalian orthologs of the Caenorhabditis elegans longevity protein Daf-16, and has an evolutionarily conserved function in the regulation of nutrient sensing and stress responses. Recent studies have shown that Foxo proteins control expression of immune system-specific genes such as II7ra in naive T cells and Foxp3 in regulatory T cells, which are crucial regulators of T cell homeostasis and tolerance. These findings reveal that the ancient Foxo pathway has been co-opted to regulate highly specialized T cell activities. The Foxo pathway probably enables a diverse and self-tolerant population of T cells in the steady state, which is an important prerequisite for the establishment of a functional adaptive immune system.
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