Journal
TRENDS IN IMMUNOLOGY
Volume 32, Issue 12, Pages 589-594Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2011.09.004
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Funding
- Grants-in-Aid for Scientific Research [21229007] Funding Source: KAKEN
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In B cells, changes in intracellular concentration of Ca2+ drive signal transduction to initiate changes in gene expression and various cellular events, including apoptosis and differentiation. B cell receptor engagement causes a transient Ca2+ flux from the endoplasmic reticulum Ca2+ store, followed by a continuous increase in intracellular Ca2+ concentration, mainly resulting from store-operated Ca2+ entry (SOCE). The recent identification of stromal interaction molecule (STIM) and Orai as essential components for SOCE has allowed researchers to probe further the role of Ca2+ signals in B cell biology. Here, we summarize the B cell signaling pathways that lead to SOCE, the role of Ca2+ signals in B cell regulatory function, and how a breakdown in the balance of Ca2+ signals is associated with immune-related disease.
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