Journal
TRENDS IN IMMUNOLOGY
Volume 32, Issue 2, Pages 73-79Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2010.12.007
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Funding
- NIH [DK61707, AR051790, AI063331, AR059688, DK091191, 2T32 HL007517]
- Uehara Memorial Foundation
- University of Michigan Comprehensive Cancer Center
- Center for Genetics in Health and Medicine (CGHM)
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The identification of several families of innate pattern recognition receptors has greatly enhanced our understanding of the host innate immune response against a variety of pathogens. One such family of innate receptors is the nucleotide-binding domain and leucine rich repeat containing receptors (NLRs). NOD2 has been characterized as a cytosolic sensor of bacteria peptidoglycan (PGN). For almost 10 years, NOD2 was assigned with the function of mediating the RICK- and nuclear factor-kappa B induced proinflammatory response triggered by PGN. Recent studies have extended the biological activity of NOD2 to include the induction of autophagy and antiviral responses, as well as mediating direct T cell activation. Here, we highlight and discuss these new findings in the context of immune activation and pathogen detection.
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