Journal
TRENDS IN IMMUNOLOGY
Volume 32, Issue 4, Pages 157-164Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2011.01.005
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Funding
- FWO-Vlaanderen [3G072810, 31507110]
- VIB, Ghent University (GROUPID consortium of the UGent MRP initiative)
- Research Foundation Flanders (FWO-Vlaanderen) [G.0875.11, G.0973.11]
- Federal Research Program [IAP 6/18]
- European Research Program FP6 ApopTrain [MRTN-CT-035624]
- Euregional PACTII
- Flemish Government [BOF09/01M00709]
- [Apo-Sys 200767]
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Cell death and injury often lead to release or exposure of intracellular molecules called damage-associated molecular patterns (DAMPs) or cell death-associated molecules. These molecules are recognized by the innate immune system by pattern recognition receptors the same receptors that detect pathogen-associated molecular patterns, thus revealing similarities between pathogen-induced and non-infectious inflammatory responses. Many DAMPs are derived from the plasma membrane, nucleus, endoplasmic reticulum and cytosol. Recently, mitochondria have emerged as other organelles that function as a source of DAMPs. Here, we highlight the significance of mitochondria! DAMPs and discuss their contribution to inflammation and development of human pathologies.
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