Journal
TRENDS IN IMMUNOLOGY
Volume 32, Issue 11, Pages 540-547Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2011.07.001
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Funding
- National Institutes of Health [HL 58108, HL55798]
- American Heart Association [10POST4160142-01]
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Atherosclerosis is an inflammatory disease of the arteries, which results in major morbidity and mortality. Immune cells initiate and sustain local inflammation. Here, we focus on how dendritic cell (DC)-mediated processes might be relevant to atherosclerosis. Although only small numbers of DCs are detected in healthy arteries, these numbers dramatically increase during atherosclerosis development. In the earliest fatty streaks, DCs are found next to the vascular endothelium. During plaque growth, new DCs are actively recruited, and their egress from the vessel wall is dampened. In the adventitia next to mature atherosclerotic lesions, tertiary lymphoid organs develop, which also contain DCs. Thus, DCs probably participate in all stages of atherosclerosis from fatty streaks to mature lesions.
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