Journal
TRENDS IN IMMUNOLOGY
Volume 32, Issue 2, Pages 57-65Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2010.12.003
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Funding
- NCI NIH HHS [P50 CA126752-05, P50 CA126752] Funding Source: Medline
- NHLBI NIH HHS [T32 HL092332-09, K08 HL098898, T32 HL092332] Funding Source: Medline
- NIA NIH HHS [R21 AG034451, R21 AG034451-02] Funding Source: Medline
- NIDDK NIH HHS [R01 DK058192, R01 DK058192-10S1] Funding Source: Medline
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Hematopoietic stem cells (HSCs) are the progenitors of all blood and immune cells, yet their role in immunity is not well understood. Most studies have focused on the ability of committed lymphoid and myeloid precursors to replenish immune cells during infection. Recent studies, however, have indicated that HSCs also proliferate in response to systemic infection and replenish effector immune cells. Inflammatory signaling molecules including interferons, tumor necrosis factor-alpha and Toll-like receptors are essential to the HSC response. Observing the biology of HSCs through the lens of infection and inflammation has led to the discovery of an array of immune-mediators that serve crucial roles in HSC regulation and function.
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