Journal
TRENDS IN IMMUNOLOGY
Volume 31, Issue 11, Pages 407-413Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2010.09.001
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Funding
- NIH [AI61570, AI74878, AI083480, F32 AI72943, F31 GM082187, T32 AI060516, T32 AI007532 08, T32 CA09140 30, T32 AI055438 06, T32 AI05528, S10RR024525]
- Burroughs Wellcome Fund
- Crohn's and Colitis Foundation of America
- University of Pennsylvania
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The recent identification of previously unrecognized innate cell populations, termed natural helper cells (NHCs), multi-potent progenitor type 2 (MPPtype2) cells, nuocytes and innate type 2 helper (Ih2) cells has provided new insights into our understanding of the cellular mechanisms that lead to the development of CD4(+) Th2 cell-dependent immunity and/or inflammation at mucosa! sites In this review, we focus on the functional significance, similarities, and differences between NHCs, MPPtype2 cells, nuocytes and Ih2 cells All four cell populations are activated by interleukin (IL)-25 and/or IL-33 and are capable of promoting Th2 cytokine responses Collectively, the identification of these cell populations might illuminate ancient evolutionary conserved pathways that are involved in the development of Th2 cytokine responses, and could be of benefit in the development of therapeutic approaches that target helminth infections and allergic diseases
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