Journal
TRENDS IN IMMUNOLOGY
Volume 31, Issue 2, Pages 63-70Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2009.12.002
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Funding
- MRC [MC_U190081986, MC_U190085848] Funding Source: UKRI
- Medical Research Council [MC_U190081986, MC_U190085848] Funding Source: researchfish
- Medical Research Council [MC_U190085848, MC_U190081986] Funding Source: Medline
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T cell-mediated inflammatory immune responses contribute to both the clearance and pathology of malaria infections; the host's ability to down-regulate inflammation once parasitemia is controlled is crucial to avoid immune-mediated pathology but remains poorly understood. Various regulatory populations of T lymphocytes can modulate inflammatory immune responses and there has been considerable recent interest in the potential for regulatory T cells to modify the outcome of both murine and human malaria infections. Here, we review these studies, focussing in particular on recent studies in humans, propose a model by which different regulatory T cell populations might contribute to the control of inflammation at different stages of infection and discuss the implications for the design of safe and effective malaria vaccines.
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