Journal
TRENDS IN IMMUNOLOGY
Volume 31, Issue 3, Pages 110-119Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2009.12.001
Keywords
-
Categories
Funding
- Austrian Research Fund (FWF) [P198810-B05, P18726-B05]
- European Union
- FP7 Large Scale Integrated Project Novel approaches to reconstitute normal immune function at old age [HEALTH-F4-2008-202156]
Ask authors/readers for more resources
Fibrosis is an important health problem, and its pathogenetic principles are still largely unknown. It can develop either spontaneously, or, more frequently, as a consequence of various underlying diseases. Irrespective of the primary cause, however, fibrotic tissue is always infiltrated by mononuclear immune cells. In most instances the reason for the attraction of these cells to fibrotic tissue and their proliferation remains to be determined; however their cytokine profile shows clear-cut proinflammatory and profibrotic characteristics. In this review, we discuss the innate and adaptive immune reactions associated with the development of fibrosis and the molecular basis of the profibrotic mechanisms taking place in systemic sclerosis (scleroderma), arteriosclerosis and pen-silicone mammary implant fibrosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available