Journal
TRENDS IN IMMUNOLOGY
Volume 30, Issue 7, Pages 325-333Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2009.05.004
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Funding
- Biotechnology and Biosciences Research Council and an Arthritis Research Campaign (ARC)
- National Institutes of Health [N01-AI-50031, AI 070343]
- John A. Hartford Foundation
- Claude D. Pepper Older Americans Independence Center at Yale University [P30 AG021342]
- Medical Research Council [G9818340B] Funding Source: researchfish
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The past decade has seen an explosion in research focusing on innate immunity. Through a wide range of mechanisms including phagocytosis, intracellular killing and activation of proinflammatory or antiviral cytokine production, the cells of the innate immune system initiate and support adaptive immunity. The effects of aging on innate immune responses remain incompletely understood, particularly in humans. Here we review advances in the study of human immunosenescence in the diverse cells of the innate immune system, including neutrophils, monocytes, macrophages, natural killer and natural killer T (NKT) cells and dendritic cells-with a focus on consequences for the response to infection or vaccination in old age.
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