Journal
TRENDS IN IMMUNOLOGY
Volume 30, Issue 8, Pages 383-391Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2009.05.007
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Funding
- Interuniversity Attraction Poles program [IAP6/18]
- Belgian Foundation
- Strategic Basis Research program
- IWT
- Centrum voor Gezwelziekten
- Ghent University
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Nuclear factor (NF)-kappa B has an important role in immunity and inappropriate NF-kappa B activity has been linked with many autoimmune and inflammatory diseases. Multiple mechanisms normally ensure the proper termination of NF-kappa B activation. In this context, the intracellular ubiquitin-editing protein A20 (also known as Tumor Necrosis Factor Alpha-Induced Protein 3 or TNFAIP3) is a key player in the negative feedback regulation of NF-kappa B signaling in response to multiple stimuli. Moreover, A20 also regulates tumor necrosis factor (TNF)-induced apoptosis. Recent genetic studies demonstrate a clear association between several mutations in the human A20 locus and immunopathologies such as Crohn's disease, rheumatoid arthritis, systemic lupus erythematosus, psoriasis and type 1 diabetes. These findings further illustrate the importance of A20 in the resolution of inflammation and the prevention of human disease.
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