Journal
TRENDS IN IMMUNOLOGY
Volume 30, Issue 9, Pages 439-446Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2009.06.001
Keywords
-
Categories
Funding
- European Research Council
- Istituto Superiore di Sanita
- MIUR
- FIRB
- Ministero della Salute
- AIRC
- European Union Sixth and Seventh Framework Programme [LSHG-CT-2005-005203, HEALTH-F4-2008-202156]
- German Research Council [GRK 1202, AN372/10-1]
Ask authors/readers for more resources
TIR8, also known as single Ig IL-1 receptor (IL-R)-related molecule, SIGIRR, is a member of the IL-1R like (ILR) family. Unlike most other members of this family, it has a single extracellular Ig domain, a long cytoplasmic tail and a Toll/IL-1R (TIR) domain with two amino acid substitutions possibly consistent with non-conventional signaling. The TIR8 structure and pattern of expression are conserved in evolution from birds to humans. Current evidence suggests that TIR8 inhibits signaling receptor complexes of IL-1 family members associated with Th1 (IL-18), Th2 (IL-33) and Th17 (IL-1) differentiation. TIR8 also dampens TLR-mediated activation. The ability to dampen signaling from ILR family members and TLRs makes TIR8 a key regulator of inflammation, cancer-related inflammation, and autoimmunity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available