Journal
TRENDS IN IMMUNOLOGY
Volume 30, Issue 12, Pages 592-602Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2009.09.009
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Funding
- National Cancer Institute of the National Institutes of Health
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Cytokines are key modulators of T cell biology, but their influence can be attenuated by suppressors of cytokine signaling (SOCS), a family of proteins consisting of eight members, SOCS1-7 and CIS. SOCS proteins regulate cytokine signals that control the polarization of CD4(+) T cells into Th1, Th2, Th17, and T regulatory cell lineages, the maturation of CD8(+) T cells from naive to stem-cell memory (Tscm), central memory (Tcm), and effector memory (Tem) states, and the activation of these lymphocytes. Understanding how SOCS family members regulate T cell maturation, differentiation, and function might prove critical in improving adoptive immunotherapy for cancer and therapies aimed at treating autoimmune and infectious diseases.
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