Journal
TRENDS IN IMMUNOLOGY
Volume 30, Issue 4, Pages 157-164Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2009.01.005
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Funding
- ALTANA AG
- [EU-FP6-NEST]
- Medical Research Council [G9818340B] Funding Source: researchfish
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Germinal centres are receiving renewed attention following recent intravital multi-photon imaging studies. These data have shed new light on longstanding questions about the spatial organisation of germinal centres, B-cell migration, selection and differentiation. Mathematical models have proven invaluable in the analysis of intravital motility data, and have predicted novel B-cell selection mechanisms that are now supported by experimental findings. We argue that mathematical modelling adds a different vantage point to experimental data and provides a quantitative and systematic analysis of hypotheses and theories in immunology. Furthermore, the well-characterised nature of the germinal centre provides an excellent proving ground for mathematical modelling.
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