Journal
TRENDS IN IMMUNOLOGY
Volume 29, Issue 1, Pages 34-40Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2007.10.004
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Funding
- Arthritis Research UK [17707] Funding Source: Medline
- Versus Arthritis [17707] Funding Source: Medline
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The maintenance of tolerance is the sine qua non of a sophisticated regulatory apparatus to prevent or dampen overzealous immune responses. In addition to the ability of B cells to prime and activate the immune system, B cells with regulatory function (Bregs) have been identified in experimental models of autoimmunity, infections, and cancer, supporting the notion that, similar to regulatory T cells (Tregs), Breg-mediated suppression is an important means for the maintenance of peripheral tolerance. This regulatory function appears to be directly mediated by the production of IL-10 and/or TGF beta and by the ability of B cells to interact with pathogenic T cells to inhibit harmful immune responses. The identification of their existence is of great relevance to the understanding of autoimmune diseases and to the development of new therapeutic strategies.
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