Journal
TRENDS IN IMMUNOLOGY
Volume 29, Issue 3, Pages 99-102Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2007.12.005
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Funding
- NIAID NIH HHS [AI57854] Funding Source: Medline
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Foxp3(+)CD4(+) T cells represent a population of naturally arising suppressor T cells that are crucial for the control of autoimmune responses. The suppressive activity of this T cell subset relies on multiple mechanisms that include secretion of anti-inflammatory factors such as TGF-beta or IL-10. Novel studies now establish that, through the generation of the immunosuppressive factor adenosine, the ectoenzymes CD39 and CD73 are important contributors to the regulatory activity of Foxp3(+)CD4(+) T cells.
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