Journal
TRENDS IN IMMUNOLOGY
Volume 29, Issue 2, Pages 51-53Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2007.11.003
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Funding
- BBSRC [BB/D008573/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D008573/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/D008573/1] Funding Source: Medline
- Wellcome Trust [079605] Funding Source: Medline
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Two recent crystal structures of membrane attack complex/perforin (MACPF) domains found in the complement and perforin families unexpectedly reveal that some proteins of the immune system share a common core fold with their bacterial targets. Although a relationship between MACPF proteins and the previously characterized bacterial cholesterol-dependent cytolysins (CDCs) is not detectable by sequence analysis, the MACPF structures show that eukaryotic defense and bacterial CDC attack share a common mechanism of membrane insertion and pore formation.
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