Journal
TRENDS IN IMMUNOLOGY
Volume 29, Issue 1, Pages 4-11Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2007.09.006
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Funding
- MRC [G0601072] Funding Source: UKRI
- Medical Research Council [G0601072] Funding Source: Medline
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Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that infects human CD4(+) T lymphocytes. Despite its presence in T cells, HTLV-1 causes little overt immunosuppression. This host-virus relationship has therefore been exploited as an excellent model system for studying the dynamic interaction between a persistent retrovirus and the normal human immune system. We use a combination of mathematical and experimental techniques to identify key factors on both sides of the in vivo host-virus interaction that significantly determine HTLV-1 proviral load and disease risk. We develop a model to describe how these factors interact to enable viral persistence.
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