Journal
TRENDS IN GENETICS
Volume 30, Issue 6, Pages 245-253Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2014.03.005
Keywords
RNA processing; R-loops; genome instability; cancer; transcriptome
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Funding
- Cancer Research Society
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes of Health Research [MOP-38096]
- National Institutes of Health [R01-CA158162]
- Roman M Babicki fellowship
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The role of normal transcription and RNA processing in maintaining genome integrity is becoming increasingly appreciated in organisms ranging from bacteria to humans. Several mutations in RNA biogenesis factors have been implicated in human cancers, but the mechanisms and potential connections to tumor genome instability are not clear. Here, we discuss how RNA-processing defects could destabilize genomes through mutagenic R-loop structures and by altering expression of genes required for genome stability. A compelling body of evidence now suggests that researchers should be directly testing these mechanisms in models of human cancer.
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