Journal
TRENDS IN GENETICS
Volume 30, Issue 12, Pages 519-520Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2014.08.005
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The word 'epimutation' is often used in a manner that can be misinterpreted. The strict definition of epimutation is a heritable change in gene activity that is not associated with a DNA mutation but rather with gain or loss of DNA methylation or other heritable modifications of chromatin. Unfortunately, there is a growing tendency in the cancer field to use the word in situations in which underlying DNA sequence changes have occurred.
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