Journal
TRENDS IN GENETICS
Volume 30, Issue 8, Pages 348-355Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2014.06.001
Keywords
long noncoding RNA; transcription; chromatin conformation; RNA-protein interactions
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Funding
- European Research Council Advanced Grant
- Medical Research Council
- Medical Research Council [MC_UU_12021/1, MC_U137761446] Funding Source: researchfish
- MRC [MC_U137761446, MC_UU_12021/1] Funding Source: UKRI
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Several nuclear localised intergenic long noncoding RNAs (IncRNAs) have been ascribed regulatory roles in transcriptional control and their number is growing rapidly. Initially, these transcripts were shown to function locally, near their sites of synthesis, by regulating the expression of neighbouring genes. More recently, IncRNAs have been demonstrated to interact with chromatin at several thousand different locations across multiple chromosomes and to modulate large-scale gene expression programs. Although the molecular mechanisms involved in targeting IncRNAs to distal binding sites remain poorly understood, the spatial organisation of the genome may have a role in specifying IncRNA function. Recent advances indicate that intergenic IncRNAs may exert more widespread effects on gene regulation than previously anticipated.
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