Journal
TRENDS IN GENETICS
Volume 28, Issue 11, Pages 566-573Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2012.06.004
Keywords
nucleotide excision repair; chromatin; transcription; development; aging; cancer
Categories
Funding
- IMMB-FORTH Intramural funds
- FP-7 Capacities 'ProFI'
- NSRF-ESPA 'Heracleitus II'
- Cooperation [EDGE 901-13/11/2009]
- THALIS 'GenAge' and 'miREG'
- ARISTEIA 'TagNER'
- ELKE [901-13/11/2009]
- Maria-Michail Manassakis Fellowship
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Nucleotide excision repair (NER) is a major DNA repair pathway that ensures that the genome remains functionally intact and is faithfully transmitted to progeny. However, defects in NER lead, in addition to cancer and aging, to developmental abnormalities whose clinical heterogeneity and varying severity cannot be fully explained by the DNA repair deficiencies. Recent work has revealed that proteins in NER play distinct roles, including some that go well beyond DNA repair. NER factors are components of protein complexes known to be involved in nucleosome remodeling, histone ubiquitination, and transcriptional activation of genes involved in nuclear receptor signaling, stem cell reprogramming, and postnatal mammalian growth. Together, these findings add new pieces to the puzzle for understanding NER and the relevance of NER defects in development and disease.
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