Journal
TRENDS IN GENETICS
Volume 28, Issue 8, Pages 409-416Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2012.03.006
Keywords
enhancer; paused polymerase; pioneer factors; robustness; gene regulatory networks
Categories
Funding
- NIGMS NIH HHS [R01 GM046638, R01 GM034431] Funding Source: Medline
Ask authors/readers for more resources
We review recently identified mechanisms of transcriptional control that ensure reliable and reproducible patterns of gene expression in natural populations of developing embryos, despite inherent fluctuations in gene regulatory processes, variations in genetic backgrounds and exposure to diverse environmental conditions. These mechanisms are not responsible for switching genes on and off. Instead, they control the fine-tuning of gene expression and ensure regulatory precision. Several such mechanisms are discussed, including redundant binding sites within transcriptional enhancers, shadow enhancers, and 'poised' enhancers and promoters, as well as the role of 'redundant' gene interactions within regulatory networks. We propose that such regulatory mechanisms provide population fitness and 'fine-tune' the spatial and temporal control of gene expression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available