Journal
TRENDS IN GENETICS
Volume 27, Issue 8, Pages 323-331Publisher
CELL PRESS
DOI: 10.1016/j.tig.2011.05.007
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Funding
- European Research Council
- Ministerio de Ciencia e Innovacion (MICINN) [BFU2008-00365]
- ICREA
- Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR)
- European Research Area for Systems Biology (ERASysBio+)
- EMBL-CRG Systems Biology Program
- European Molecular Biology Organization
- ICREA Funding Source: Custom
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'Disease-causing' mutations do not cause disease in all individuals. One possible important reason for this is that the outcome of a mutation can depend upon other genetic variants in a genome. These epistatic interactions between mutations occur both within and between molecules, and studies in model organisms show that they are extremely prevalent. However, epistatic interactions are still poorly understood at the molecular level, and consequently difficult to predict de novo. Here I provide an overview of our current understanding of the molecular mechanisms that can cause epistasis, and areas where more research is needed. A more complete understanding of epistasis will be vital for making accurate predictions about the phenotypes of individuals.
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