Journal
TRENDS IN GENETICS
Volume 27, Issue 5, Pages 177-185Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2011.02.002
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Funding
- le Ligue Nationale contre le Cancer
- European Commission [LSHG-CT-2004-503433, ACI-2007-Canceropole IdF]
- ANR [ANR-09-BLAN-0257-01]
- ERC [2009-AdG_20090506]
- Agence Nationale de la Recherche (ANR) [ANR-09-BLAN-0257] Funding Source: Agence Nationale de la Recherche (ANR)
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Heterochromatin at pericentric satellites, characterized by a specific chromatin signature and chromocenter organization, is of paramount importance for genome function. Re-establishment of this organization after fertilization takes place in the context of genome-wide epigenetic reprogramming. We review how the asymmetry in histone variants and post-translational modifications between paternal and maternal genomes and their respective pericentric heterochromatin domains evolve during early cleavage stages in mouse. We draw a parallel between these data and the burst of pericentric satellite transcription that occurs concomitantly with the dynamic reorganization of the pericentric domains into chromocenters in two-cell stage embryos. Based on this new angle, we propose that a crucial developmental transition at the two-cell stage allows chromocenter formation by involving non-coding satellite transcripts to trigger specific chromatin changes.
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