Journal
TRENDS IN GENETICS
Volume 25, Issue 5, Pages 226-233Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2009.03.005
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Funding
- Biotechnology and Biological Sciences Research Council [BB/H002006/1] Funding Source: Medline
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In species with highly differentiated sex chromosomes, imbalances in gene dosage between the sexes can affect overall organismal fitness. Regulatory mechanisms were discovered in several unrelated animals, which counter gene-dose differences between females and males, and these early findings suggested that dosage-compensating mechanisms were required for sex-chromosome evolution. However, recent reports in birds and moths contradict this view because these animals locally compensate only a few genes on the sex chromosomes, leaving the majority with different expression levels in males and females. These findings warrant a re-examination of the evolutionary forces underlying dosage compensation.
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