Journal
TRENDS IN GENETICS
Volume 25, Issue 4, Pages 152-155Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2009.03.001
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- Science Foundation Ireland
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In yeast and worm, duplicate genes overlap in function so that deleting one of a pair from the genome is less likely to be lethal than deleting a singleton gene. By contrast, previous analyses showed that mouse duplicate genes were as essential as singletons. We show that the relationship between gene duplication and essentiality is complex in multicellular organisms, with developmental genes and genes that were duplicated by whole genome duplication being more essential than other duplicated genes.
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