Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 25, Issue 4, Pages 168-177Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2013.12.004
Keywords
brown adipose tissue; energy expenditure; uncoupling protein 1
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Funding
- National Institutes of Health (NIH) [R01 DK077097, P30 DK036836]
- American Diabetes Association
- Harvard Stem Cell Institute
- NIH [T32 DK007260-33, F32 DK091996]
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Brown adipose tissue (BAT) dissipates energy As heat to maintain optimal thermogenesis and to contribute to energy expenditure in rodents and possibly humans. The energetic processes executed by BAT require a readily-available fuel supply, which includes glucose and fatty acids (FAs). FAs become available by cellular uptake, de novo lipogenesis, and multilocular lipid droplets in brown adipocytes. BAT also possesses a great capacity for glucose uptake and metabolism, and an ability to regulate insulin sensitivity. These properties make BAT an appealing target for the treatment of obesity, diabetes, and other metabolic disorders. Recent research has provided a better understanding of the processes of fuel utilization carried out by brown adipocytes, which is the focus of the current review.
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