Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 25, Issue 12, Pages 620-627Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2014.08.005
Keywords
beta cell; autophagy; obesity; ER stress; islet amyloid
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Funding
- Global Research Laboratory Grant from the National Research Foundation of Korea [2010-00347]
- National Research Foundation of Korea [2014M3A9D8034459]
- National Research Foundation of Korea [2014M3A9D8034459] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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While the role of autophagy in the physiology of endocrine organs and the development of metabolic disorders or diabetes has been investigated, the relationship between the pancreatic islet and autophagy has not been explored extensively. In this review, studies on the possible involvement of dysregulated autophagy in the pathogenesis of metabolic syndrome and diabetes will be summarized with an emphasis on the autophagic process in pancreatic islet cells. Novel findings regarding the role of autophagy in human beta cell pathology and the development of type 2 diabetes (T2D) characterized by islet amyloid deposition will be discussed. Careful design of agents enhancing autophagic activity in beta cells might serve as a novel approach towards therapeutics for the treatment of diabetes.
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